Bluestem Pilot Study

Psilocybin-Assisted Therapy for Veterans with Treatment-Resistant Depression

Pioneering access to psilocybin-assisted therapy for Canadian veterans who have not found relief with conventional treatments.

Bluestem API Inc. is conducting a pilot study for veterans living with Treatment-Resistant Depression (TRD).

This innovative program is enabled through Health Canada’s Special Access Program (SAP), which allows patients with serious or life-threatening conditions to access therapies not yet widely available.

If you are a veteran who has tried standard therapies without success, this may be an opportunity to find new hope.

Who Can Apply

You may be eligible if:

‍You are a Canadian veteran, age 18 or older.

You have a diagnosis of Treatment-Resistant Depression (inadequate response to at least one antidepressant trial at an adequate dose and duration).

You are willing to apply for access through Health Canada’s Special Access Program (we will guide you through this process).

You are medically and psychologically stable enough to participate in psilocybin-assisted therapy, as determined by clinical screening.

Applicants with co-occurring conditions such as PTSD, generalized anxiety disorder, or end-of-life anxiety may also be considered, but Treatment-Resistant Depression must be present for eligibility.

Who Can Apply

You may not be eligible if:

You have a personal or family history of psychosis or bipolar I disorder.

You have uncontrolled medical conditions (e.g., serious cardiovascular disease).

You are currently pregnant or breastfeeding.


You have an active substance use disorder that would interfere with treatment.

You are unable to provide informed consent or commit to study procedures.

The SAP Application Process

All participants must submit an application to Health Canada’s Special Access Program (SAP).

To make this process as simple as possible, Bluestem provides two pathways through our SAGE App:

Flow 1 – Direct Intake

Complete a secure questionnaire in our SAGE App.

Provide details about your medical history and previous therapies you’ve tried.

Our system will generate the SAP application for you, ready for clinician review.

Apply Now

Flow 2 – PDF Upload

Download a PDF template for your doctor or therapist to fill out.
Upload the completed PDF back into our SAGE App.


The system will auto-populate your application fields for you to quickly review and verify.


Both options are designed to save time, reduce errors, and ensure your application is complete before submission.

Download Form

What to Expect if Accepted

Eligibility Review

Our clinical team confirms readiness and safety to participate.

Eligibility Review

Our clinical team confirms readiness and safety to participate.

Eligibility Review

Our clinical team confirms readiness and safety to participate.

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